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The Open Environmental Journal, 2008, 2, 54-61
Methodological Aspects of Epidemiological Studies on the Use of Mobile Phones and their Association with Brain Tumors
Martes 3 de junio de 2008 · 2014 lecturas
Methodological Aspects of Epidemiological Studies on the Use of Mobile
Phones and their Association with Brain Tumors
Lennart Hardell*,1, Michael Carlberg1 and Kjell Hansson Mild2
1Department of Oncology, University Hospital, SE-701 85, Sweden
2Department of Radiation Physics, Umeå University, SE-901 87 Umeå, Sweden
Abstract: Our case-control studies were the first to report an association between the use of mobile or cordless phones
and brain tumors; glioma and acoustic neuroma. Criticism of these results has been based partly on results from the Interphone
studies conducted under the auspice of the International Agency for Research on Cancer (IARC). Here, we compare
study design and epidemiological methods used in our studies and the Interphone studies. We conclude that while our
results appear sound and reliable, several of the Interphone findings display differential misclassification of exposure due
to observational and recall bias, for example, following low participation rates in both cases and controls and bed-side
computer guided interviews of cases rather than blinded interviews of cases and controls. However, as we have presented
elsewhere, there seems to be a consistent pattern of an association between mobile phone use and ipsilateral glioma and
acoustic neuroma using > 10 years latency period.
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