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JOURNAL OF CLINICAL ONCOLOGY Published Ahead of Print on October 13, 2009
Mobile Phone Use and Risk of Tumors: A Meta-Analysis: "In sum, in our meta-analyses of case-control studies, we found evidence linking mobile phone use to an increased risk of tumors, especially among users of 10 or more years".
Lunes 19 de octubre de 2009 · 1572 lecturas
Mobile Phone Use and Risk of Tumors: A Meta-Analysis
A B S T R A C T
Purpose
Case-control studies have reported inconsistent findings regarding the association between
mobile phone use and tumor risk. We investigated these associations using a meta-analysis.
Methods
We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library in August 2008. Two
evaluators independently reviewed and selected articles based on predetermined selection criteria.
Results
Of 465 articles meeting our initial criteria, 23 case-control studies, which involved 37,916
participants (12,344 patient cases and 25,572 controls), were included in the final analyses.
Compared with never or rarely having used a mobile phone, the odds ratio for overall use was 0.98
for malignant and benign tumors (95% CI, 0.89 to 1.07) in a random-effects meta-analysis of all 23
studies. However, a significant positive association (harmful effect) was observed in a randomeffects
meta-analysis of eight studies using blinding, whereas a significant negative association
(protective effect) was observed in a fixed-effects meta-analysis of 15 studies not using blinding.
Mobile phone use of 10 years or longer was associated with a risk of tumors in 13 studies
reporting this association (odds ratio - 1.18; 95% CI, 1.04 to 1.34). Further, these findings were
also observed in the subgroup analyses by methodologic quality of study. Blinding and methodologic
quality of study were strongly associated with the research group.
Conclusion
The current study found that there is possible evidence linking mobile phone use to an increased
risk of tumors from a meta-analysis of low-biased case-control studies. Prospective cohort studies
providing a higher level of evidence are needed.
J Clin Oncol 27. © 2009 by American Society of Clinical Oncology
